He married Tabitha about 1780 in Rowan County, North Carolina. They lived in a part of the county that became Stokes County in 1789.
Tabitha and Isaac's children may have included:
Phebe Pitts (1788, ),
Martha Pitts (1789, married John Stagg),
Mary Pitts (1790),
Dorcas Pitts (1792),
Levi Pitts (1795, married Mary Salisbury),
Isaac Pitts, Jr.
The 1815, 1819, 1820 tax lists for the Deep River District in Stokes County, North Carolina included Isaac.
The 1821 tax list for the Deep River District included Isaac Pitts, Jr.
The 1822 tax list for the Deep River District included Isaac and Isaac, Jr.
Rowan County, North Carolina was formed in 1753 from the northern part of Anson County. In 1770, the eastern part was combined with the western part of Orange County to become Guilford County. In 1771 the northeastern part of what remained of Rowan County became Surry County. In 1777 the western part of Rowan County became Burke County. In 1788 the western part became Iredell County. In 1822 the eastern part became Davidson County. Finally, in 1836 the part of Rowan County north of the South Yadkin River became Davie County.